diff --git a/Cargo.lock b/Cargo.lock
index 634e3cc82..805c4d833 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -278,9 +278,9 @@ dependencies = [
 
 [[package]]
 name = "indexmap"
-version = "1.8.1"
+version = "1.7.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "0f647032dfaa1f8b6dc29bd3edb7bbef4861b8b8007ebb118d6db284fd59f6ee"
+checksum = "bc633605454125dec4b66843673f01c7df2b89479b32e0ed634e43a91cff62a5"
 dependencies = [
  "autocfg",
  "hashbrown",
@@ -416,9 +416,9 @@ checksum = "e2abad23fbc42b3700f2f279844dc832adb2b2eb069b2df918f455c4e18cc646"
 
 [[package]]
 name = "libc"
-version = "0.2.125"
+version = "0.2.126"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "5916d2ae698f6de9bfb891ad7a8d65c09d232dc58cc4ac433c7da3b2fd84bc2b"
+checksum = "349d5a591cd28b49e1d1037471617a32ddcda5731b99419008085f72d5a53836"
 
 [[package]]
 name = "libloading"
@@ -565,9 +565,9 @@ dependencies = [
 
 [[package]]
 name = "once_cell"
-version = "1.10.0"
+version = "1.12.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "87f3e037eac156d1775da914196f0f37741a274155e34a0b7e427c35d2a2ecb9"
+checksum = "7709cef83f0c1f58f666e746a08b21e0085f7440fa6a29cc194d68aac97a4225"
 
 [[package]]
 name = "parking_lot"
@@ -638,9 +638,9 @@ dependencies = [
 
 [[package]]
 name = "petgraph"
-version = "0.6.0"
+version = "0.6.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "4a13a2fa9d0b63e5f22328828741e523766fff0ee9e779316902290dff3f824f"
+checksum = "51b305cc4569dd4e8765bab46261f67ef5d4d11a4b6e745100ee5dad8948b46c"
 dependencies = [
  "fixedbitset",
  "indexmap",
@@ -865,9 +865,9 @@ dependencies = [
 
 [[package]]
 name = "regex"
-version = "1.5.5"
+version = "1.5.6"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "1a11647b6b25ff05a515cb92c365cec08801e83423a235b51e231e1808747286"
+checksum = "d83f127d94bdbcda4c8cc2e50f6f84f4b611f69c902699ca385a39c3a75f9ff1"
 dependencies = [
  "aho-corasick",
  "memchr",
@@ -876,9 +876,9 @@ dependencies = [
 
 [[package]]
 name = "regex-syntax"
-version = "0.6.25"
+version = "0.6.26"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "f497285884f3fcff424ffc933e56d7cbca511def0c9831a7f9b5f6153e3cc89b"
+checksum = "49b3de9ec5dc0a3417da371aab17d729997c15010e7fd24ff707773a33bddb64"
 
 [[package]]
 name = "remove_dir_all"
diff --git a/flake.lock b/flake.lock
index 8cb0e8dd8..771e487fd 100644
--- a/flake.lock
+++ b/flake.lock
@@ -2,16 +2,16 @@
   "nodes": {
     "nixpkgs": {
       "locked": {
-        "lastModified": 1652559422,
-        "narHash": "sha256-jPVTNImBTUIFdtur+d4IVot6eXmsvtOcBm0TzxmhWPk=",
+        "lastModified": 1653354321,
+        "narHash": "sha256-AMUhX1Ch0KMDWCze6KAntwlJ1iFp0fLK2TTW9Mj85WY=",
         "owner": "NixOS",
         "repo": "nixpkgs",
-        "rev": "8b3398bc7587ebb79f93dfeea1b8c574d3c6dba1",
+        "rev": "b80531b35cbcddcaf74ceb685b3a0847c134cbe1",
         "type": "github"
       },
       "original": {
         "owner": "NixOS",
-        "ref": "nixos-21.11",
+        "ref": "release-22.05",
         "repo": "nixpkgs",
         "type": "github"
       }
diff --git a/flake.nix b/flake.nix
index c2535f196..813d7ea5e 100644
--- a/flake.nix
+++ b/flake.nix
@@ -1,7 +1,7 @@
 {
   description = "The third-generation ARTIQ compiler";
 
-  inputs.nixpkgs.url = github:NixOS/nixpkgs/nixos-21.11;
+  inputs.nixpkgs.url = github:NixOS/nixpkgs/release-22.05;
 
   outputs = { self, nixpkgs }:
     let
@@ -21,7 +21,7 @@
               };
             };
             passthru.cargoLock = cargoLock;
-            nativeBuildInputs = [ pkgs.python3 pkgs.llvmPackages_13.clang-unwrapped pkgs.llvmPackages_13.llvm.out llvm-nac3 ];
+            nativeBuildInputs = [ pkgs.python3 pkgs.llvmPackages_14.clang-unwrapped pkgs.llvmPackages_14.llvm.out llvm-nac3 ];
             buildInputs = [ pkgs.python3 llvm-nac3 ];
             checkInputs = [ (pkgs.python3.withPackages(ps: [ ps.numpy ])) ];
             checkPhase =
@@ -55,7 +55,7 @@
 
         # LLVM PGO support
         llvm-nac3-instrumented = pkgs.callPackage ./nix/llvm {
-          stdenv = pkgs.llvmPackages_13.stdenv;
+          stdenv = pkgs.llvmPackages_14.stdenv;
           extraCmakeFlags = [ "-DLLVM_BUILD_INSTRUMENTED=IR" ];
         };
         nac3artiq-instrumented = pkgs.python3Packages.toPythonModule (
@@ -63,13 +63,13 @@
             name = "nac3artiq-instrumented";
             src = self;
             inherit (nac3artiq) cargoLock;
-            nativeBuildInputs = [ pkgs.python3 pkgs.llvmPackages_13.clang-unwrapped pkgs.llvmPackages_13.llvm.out llvm-nac3-instrumented ];
+            nativeBuildInputs = [ pkgs.python3 pkgs.llvmPackages_14.clang-unwrapped pkgs.llvmPackages_14.llvm.out llvm-nac3-instrumented ];
             buildInputs = [ pkgs.python3 llvm-nac3-instrumented ];
             cargoBuildFlags = [ "--package" "nac3artiq" "--features" "init-llvm-profile" ];
             doCheck = false;
             configurePhase =
               ''
-              export CARGO_TARGET_X86_64_UNKNOWN_LINUX_GNU_RUSTFLAGS="-C link-arg=-L${pkgs.llvmPackages_13.compiler-rt}/lib/linux -C link-arg=-lclang_rt.profile-x86_64"
+              export CARGO_TARGET_X86_64_UNKNOWN_LINUX_GNU_RUSTFLAGS="-C link-arg=-L${pkgs.llvmPackages_14.compiler-rt}/lib/linux -C link-arg=-lclang_rt.profile-x86_64"
               '';
             installPhase =
               ''
@@ -97,8 +97,8 @@
           ];
           buildInputs = [
             (python3-mimalloc.withPackages(ps: [ ps.numpy ps.jsonschema nac3artiq-instrumented ]))
-            pkgs.lld_13
-            pkgs.llvmPackages_13.llvm.out
+            pkgs.lld_14
+            pkgs.llvmPackages_14.llvm.out
           ];
           phases = [ "buildPhase" "installPhase" ];
           buildPhase =
@@ -118,7 +118,7 @@
             '';
         };
         llvm-nac3-pgo = pkgs.callPackage ./nix/llvm {
-          stdenv = pkgs.llvmPackages_13.stdenv;
+          stdenv = pkgs.llvmPackages_14.stdenv;
           extraCmakeFlags = [ "-DLLVM_PROFDATA_FILE=${nac3artiq-profile}/llvm.profdata" ];
         };
         nac3artiq-pgo = pkgs.python3Packages.toPythonModule (
@@ -126,7 +126,7 @@
             name = "nac3artiq-pgo";
             src = self;
             inherit (nac3artiq) cargoLock;
-            nativeBuildInputs = [ pkgs.python3 pkgs.llvmPackages_13.clang-unwrapped pkgs.llvmPackages_13.llvm.out llvm-nac3-pgo ];
+            nativeBuildInputs = [ pkgs.python3 pkgs.llvmPackages_14.clang-unwrapped pkgs.llvmPackages_14.llvm.out llvm-nac3-pgo ];
             buildInputs = [ pkgs.python3 llvm-nac3-pgo ];
             cargoBuildFlags = [ "--package" "nac3artiq" ];
             cargoTestFlags = [ "--package" "nac3ast" "--package" "nac3parser" "--package" "nac3core" "--package" "nac3artiq" ];
@@ -147,12 +147,12 @@
         buildInputs = with pkgs; [
           # build dependencies
           packages.x86_64-linux.llvm-nac3
-          llvmPackages_13.clang-unwrapped  # IRRT
-          pkgs.llvmPackages_13.llvm.out    # IRRT
+          llvmPackages_14.clang-unwrapped  # IRRT
+          pkgs.llvmPackages_14.llvm.out    # IRRT
           cargo
           rustc
           # runtime dependencies
-          lld_13
+          lld_14
           (packages.x86_64-linux.python3-mimalloc.withPackages(ps: [ ps.numpy ]))
           # development tools
           cargo-insta