diff --git a/flake.lock b/flake.lock
new file mode 100644
index 000000000..5e5b1013f
--- /dev/null
+++ b/flake.lock
@@ -0,0 +1,61 @@
+{
+  "nodes": {
+    "nixpkgs": {
+      "locked": {
+        "lastModified": 1628696776,
+        "narHash": "sha256-K8+/IQNZDZltIu/KSf+Tz01OwNzTGgTch0ktMOWcxLg=",
+        "owner": "NixOS",
+        "repo": "nixpkgs",
+        "rev": "927ce1afc1db40869a463a37ea2738c27d425f80",
+        "type": "github"
+      },
+      "original": {
+        "owner": "NixOS",
+        "ref": "nixos-21.05",
+        "repo": "nixpkgs",
+        "type": "github"
+      }
+    },
+    "root": {
+      "inputs": {
+        "nixpkgs": "nixpkgs",
+        "src-pythonparser": "src-pythonparser",
+        "src-sipyco": "src-sipyco"
+      }
+    },
+    "src-pythonparser": {
+      "flake": false,
+      "locked": {
+        "lastModified": 1628731931,
+        "narHash": "sha256-eaGuXyrkvpBPNJVKoihnoqvhoWvqaTvztTdKb+7BJfc=",
+        "owner": "m-labs",
+        "repo": "pythonparser",
+        "rev": "f6be5a1bfe44c05ffd36c8016858175954b9722d",
+        "type": "github"
+      },
+      "original": {
+        "owner": "m-labs",
+        "repo": "pythonparser",
+        "type": "github"
+      }
+    },
+    "src-sipyco": {
+      "flake": false,
+      "locked": {
+        "lastModified": 1623807309,
+        "narHash": "sha256-FTRAS4RjqDOygu6+cP8mKbZHu/YZ7YKpEe2gSzJc9rk=",
+        "owner": "m-labs",
+        "repo": "sipyco",
+        "rev": "20c946aad78872fe60b78d9b57a624d69f3eea47",
+        "type": "github"
+      },
+      "original": {
+        "owner": "m-labs",
+        "repo": "sipyco",
+        "type": "github"
+      }
+    }
+  },
+  "root": "root",
+  "version": 7
+}
diff --git a/flake.nix b/flake.nix
new file mode 100644
index 000000000..800212727
--- /dev/null
+++ b/flake.nix
@@ -0,0 +1,107 @@
+{
+  description = "A leading-edge control system for quantum information experiments";
+
+  inputs.nixpkgs.url = github:NixOS/nixpkgs/nixos-21.05;
+  inputs.src-sipyco = { url = github:m-labs/sipyco; flake = false; };
+  inputs.src-pythonparser = { url = github:m-labs/pythonparser; flake = false; };
+
+  outputs = { self, nixpkgs, src-sipyco, src-pythonparser }: with import nixpkgs { system = "x86_64-linux"; }; rec {
+    packages.x86_64-linux = rec {
+      sipyco = python3Packages.buildPythonPackage {
+        name = "sipyco";
+        src = src-sipyco;
+        propagatedBuildInputs = with python3Packages; [ pybase64 numpy ];
+      };
+
+      pythonparser = python3Packages.buildPythonPackage {
+        name = "pythonparser";
+        src = src-pythonparser;
+        doCheck = false;
+        propagatedBuildInputs = with python3Packages; [ regex ];
+      };
+
+      qasync = python3Packages.buildPythonPackage rec {
+        pname = "qasync";
+        version = "0.10.0";
+        src = fetchFromGitHub {
+          owner = "CabbageDevelopment";
+          repo = "qasync";
+          rev = "v${version}";
+          sha256 = "1zga8s6dr7gk6awmxkh4pf25gbg8n6dv1j4b0by7y0fhi949qakq";
+        };
+        propagatedBuildInputs = [ python3Packages.pyqt5 ];
+        checkInputs = [ python3Packages.pytest ];
+        checkPhase = ''
+          pytest -k 'test_qthreadexec.py' # the others cause the test execution to be aborted, I think because of asyncio
+        '';
+      };
+
+      outputcheck = python3Packages.buildPythonApplication rec {
+        pname = "outputcheck";
+        version = "0.4.2";
+        src = fetchFromGitHub {
+          owner = "stp";
+          repo = "OutputCheck";
+          rev = "e0f533d3c5af2949349856c711bf4bca50022b48";
+          sha256 = "1y27vz6jq6sywas07kz3v01sqjd0sga9yv9w2cksqac3v7wmf2a0";
+        };
+        prePatch = "echo ${version} > RELEASE-VERSION";
+      };
+
+      libartiq-support = stdenv.mkDerivation {
+        name = "libartiq-support";
+        src = self;
+        buildInputs = [ rustc ];
+        buildPhase = ''
+          # Obviously, #[feature()] can in fact be used on the stable channel, contrary to what the rustc error message says.
+          # You just need to set this obscure RUSTC_BOOTSTRAP environment variable.
+          RUSTC_BOOTSTRAP=1 rustc $src/artiq/test/libartiq_support/lib.rs -Cpanic=unwind -g
+        '';
+        installPhase = ''
+          mkdir $out
+          cp libartiq_support.so $out
+        '';
+      };
+
+      artiq = python3Packages.buildPythonPackage rec {
+        pname = "artiq";
+        version = "7.0-dev";
+        src = self;
+
+        preBuild = "export VERSIONEER_OVERRIDE=${version}";
+
+        nativeBuildInputs = [ qt5.wrapQtAppsHook ];
+        # keep llvm_x and lld_x in sync with llvmlite
+        propagatedBuildInputs = [ llvm_9 lld_9 sipyco pythonparser ]
+          ++ (with python3Packages; [ pyqtgraph pygit2 numpy dateutil scipy prettytable pyserial python-Levenshtein h5py pyqt5 qasync llvmlite ]);
+
+        dontWrapQtApps = true;
+        postFixup = ''
+          wrapQtApp "$out/bin/artiq_dashboard"
+          wrapQtApp "$out/bin/artiq_browser"
+          wrapQtApp "$out/bin/artiq_session"
+        '';
+
+        # Modifies PATH to pass the wrapped python environment (i.e. python3.withPackages(...) to subprocesses.
+        # Allows subprocesses using python to find all packages you have installed
+        makeWrapperArgs = [
+          ''--run 'if [ ! -z "$NIX_PYTHONPREFIX" ]; then export PATH=$NIX_PYTHONPREFIX/bin:$PATH;fi' ''
+          "--set FONTCONFIG_FILE ${fontconfig.out}/etc/fonts/fonts.conf"
+        ];
+
+        # FIXME: automatically propagate lld_9 llvm_9 dependencies
+        checkInputs = [ lld_9 llvm_9 outputcheck lit ];
+        checkPhase = ''
+          python -m unittest discover -v artiq.test
+
+          TESTDIR=`mktemp -d`
+          cp --no-preserve=mode,ownership -R $src/artiq/test/lit $TESTDIR
+          # FIXME: some tests fail
+          #LIBARTIQ_SUPPORT=${libartiq-support}/libartiq_support.so lit -v $TESTDIR/lit
+          '';
+      };
+    };
+
+    defaultPackage.x86_64-linux = python3.withPackages(ps: [ packages.x86_64-linux.artiq ]);
+  };
+}