diff --git a/artiq/devices/pxi6733/__init__.py b/artiq/devices/pxi6733/__init__.py
deleted file mode 100644
index e69de29bb..000000000
diff --git a/artiq/devices/pxi6733/driver.py b/artiq/devices/pxi6733/driver.py
deleted file mode 100644
index 951fd581c..000000000
--- a/artiq/devices/pxi6733/driver.py
+++ /dev/null
@@ -1,141 +0,0 @@
-# Yann Sionneau <ys@m-labs.hk>, 2015
-
-from ctypes import byref, c_ulong, create_string_buffer
-import logging
-
-import numpy as np
-
-
-logger = logging.getLogger(__name__)
-
-
-class DAQmxSim:
-    def load_sample_values(self, values):
-        pass
-
-    def close(self):
-        pass
-
-    def ping(self):
-        return True
-
-
-class DAQmx:
-    """NI PXI6733 DAQ interface."""
-
-    def __init__(self, channels, clock):
-        """
-        :param channels: List of channels as a string, following
-            the physical channels lists and ranges NI-DAQmx syntax.
-
-            Example: Dev1/ao0, Dev1/ao1:ao3
-        :param clock: Clock source terminal as a string, following
-            NI-DAQmx terminal names syntax.
-
-            Example: PFI5
-        """
-
-        import PyDAQmx as daq
-
-        self.channels = channels.encode()
-        self.clock = clock.encode()
-        self.task = None
-        self.daq = daq
-
-    def _done_callback(self, taskhandle, status, callback_data):
-        if taskhandle != self.task:
-            logger.warning("done callback called with unexpected task")
-        else:
-            self.clear_pending_task()
-
-    def ping(self):
-        try:
-            data_len = 128
-            data = create_string_buffer(data_len)
-            self.daq.DAQmxGetSysDevNames(data, data_len)
-            logger.debug("Device names: %s", data.value)
-        except:
-            return False
-        return data.value != ""
-
-    def load_sample_values(self, sampling_freq, values):
-        """Load sample values into PXI 6733 device.
-
-        This loads sample values into the PXI 6733 device.
-        The device will output samples at each clock rising edge.
-        The device waits for a clock rising edge to output the first sample.
-
-        When using several channels simultaneously, you can either concatenate
-        the values for the different channels in a 1-dimensional ``values``
-        numpy ndarray.
-
-        Example:
-
-        >>> values = np.array([ch0_samp0, ch0_samp1, ch1_samp0, ch1_samp1],
-                              dtype=float)
-
-        In this example the first two samples will be output via the first
-        channel and the two following samples will be output via the second
-        channel.
-
-        Or you can use a 2-dimensional numpy ndarray like this:
-
-        >>> values = np.array([[ch0_samp0, ch0_samp1],[ch1_samp0, ch1_samp1]],
-                              dtype=float)
-
-        Any call to this method will cancel any previous task even if it has
-        not yet completed.
-
-        :param sampling_freq: The sampling frequency in samples per second.
-        :param values: A numpy ndarray of sample values (in volts) to load in
-            the device.
-        """
-
-        self.clear_pending_task()
-        values = values.flatten()
-        t = self.daq.Task()
-        t.CreateAOVoltageChan(self.channels, b"",
-                              min(values), max(values)+1,
-                              self.daq.DAQmx_Val_Volts, None)
-
-        channel_number = (c_ulong*1)()
-        t.GetTaskNumChans(channel_number)
-        nb_values = len(values)
-        if nb_values % channel_number[0]:
-            self.daq.DAQmxClearTask(t.taskHandle)
-            raise ValueError("The size of the values array must be a multiple "
-                             "of the number of channels ({})"
-                             .format(channel_number[0]))
-        samps_per_channel = nb_values // channel_number[0]
-
-        t.CfgSampClkTiming(self.clock, sampling_freq,
-                           self.daq.DAQmx_Val_Rising,
-                           self.daq.DAQmx_Val_FiniteSamps, samps_per_channel)
-        num_samps_written = self.daq.int32()
-        values = np.require(values, dtype=float,
-                            requirements=["C_CONTIGUOUS", "WRITEABLE"])
-        ret = t.WriteAnalogF64(samps_per_channel, False, 0,
-                               self.daq.DAQmx_Val_GroupByChannel, values,
-                               byref(num_samps_written), None)
-        if num_samps_written.value != samps_per_channel:
-            raise IOError("Error: only {} sample values per channel were"
-                          "written".format(num_samps_written.value))
-        if ret:
-            raise IOError("Error while writing samples to the channel buffer")
-
-        done_cb = self.daq.DAQmxDoneEventCallbackPtr(self._done_callback)
-        self.task = t.taskHandle
-        self.daq.DAQmxRegisterDoneEvent(t.taskHandle, 0, done_cb, None)
-        t.StartTask()
-
-    def clear_pending_task(self):
-        """Clear any pending task."""
-
-        if self.task is not None:
-            self.daq.DAQmxClearTask(self.task)
-            self.task = None
-
-    def close(self):
-        """Free any allocated resources."""
-
-        self.clear_pending_task()
diff --git a/artiq/devices/pxi6733/mediator.py b/artiq/devices/pxi6733/mediator.py
deleted file mode 100644
index 2ae2704d1..000000000
--- a/artiq/devices/pxi6733/mediator.py
+++ /dev/null
@@ -1,180 +0,0 @@
-import numpy as np
-
-from artiq.language.core import *
-from artiq.language.units import *
-from artiq.wavesynth.compute_samples import Synthesizer
-
-
-class SegmentSequenceError(Exception):
-    """Raised when attempting to play back a named segment which is not the
-    next in the sequence."""
-    pass
-
-
-class InvalidatedError(Exception):
-    """Raised when attemting to use a frame or segment that has been
-    invalidated (due to disarming the DAQmx)."""
-    pass
-
-
-class ArmError(Exception):
-    """Raised when attempting to arm an already armed DAQmx, to modify the
-    program of an armed DAQmx, or to play a segment on a disarmed DAQmx."""
-    pass
-
-
-def _ceil_div(a, b):
-    return (a + b - 1)//b
-
-
-def _compute_duration_mu(nsamples, ftw, acc_width):
-    # This returns the precise duration so that the clock can be stopped
-    # exactly at the next rising edge (RTLink commands take precedence over
-    # toggling from the accumulator).
-    # If segments are played continuously, replacement of the stop command
-    # will keep the clock running. If the FTW is not a power of two, note that
-    # the accumulator is reset at that time, which causes jitter and frequency
-    # inaccuracy.
-    # Formally:
-    #    duration     *ftw >= nsamples*2**acc_width
-    #   (duration - 1)*ftw <  nsamples*2**acc_width 
-    return _ceil_div(nsamples*2**acc_width, ftw)
-
-
-class _Segment:
-    def __init__(self, frame, segment_number):
-        self.frame = frame
-        self.segment_number = segment_number
-
-        self.lines = []
-
-        # for @kernel
-        self.core = frame.daqmx.core
-
-    def add_line(self, duration, channel_data):
-        if self.frame.invalidated:
-            raise InvalidatedError
-        if self.frame.daqmx.armed:
-            raise ArmError
-        self.lines.append((duration, channel_data))
-
-    def get_sample_count(self):
-        return sum(duration for duration, _ in self.lines)
-
-    @kernel
-    def advance(self):
-        if self.frame.invalidated:
-            raise InvalidatedError
-        if not self.frame.daqmx.armed:
-            raise ArmError
-        # If the frame is currently being played, check that we are next.
-        if (self.frame.daqmx.next_segment >= 0
-                and self.frame.daqmx.next_segment != self.segment_number):
-            raise SegmentSequenceError
-        self.frame.advance()
-
-
-class _Frame:
-    def __init__(self, daqmx):
-        self.daqmx = daqmx
-        self.segments = []
-        self.segment_count = 0  # == len(self.segments), used in kernel
-
-        self.invalidated = False
-
-        # for @kernel
-        self.core = self.daqmx.core
-
-    def create_segment(self, name=None):
-        if self.invalidated:
-            raise InvalidatedError
-        if self.daqmx.armed:
-            raise ArmError
-        segment = _Segment(self, self.segment_count)
-        if name is not None:
-            if hasattr(self, name):
-                raise NameError("Segment name already exists")
-            setattr(self, name, segment)
-        self.segments.append(segment)
-        self.segment_count += 1
-        return segment
-
-    def _arm(self):
-        self.segment_delays = [
-            _compute_duration_mu(s.get_sample_count(),
-                                 self.daqmx.sample_rate,
-                                 self.daqmx.clock.acc_width)
-            for s in self.segments]
-
-    def _invalidate(self):
-        self.invalidated = True
-
-    def _get_samples(self):
-        program = [[
-            {
-                "dac_divider": 1,
-                "duration": duration,
-                "channel_data": channel_data,
-            } for segment in self.segments
-                for duration, channel_data in segment.lines]]
-        synth = Synthesizer(self.daqmx.channel_count, program)
-        synth.select(0)
-        # not setting any trigger flag in the program causes the whole
-        # waveform to be computed here for all segments.
-        # slicing the segments is done by stopping the clock.
-        return synth.trigger()
-
-    @kernel
-    def advance(self):
-        if self.invalidated:
-            raise InvalidatedError
-        if not self.daqmx.armed:
-            raise ArmError
-
-        self.daqmx.clock.set(self.daqmx.sample_rate)
-        delay_mu(self.segment_delays[self.daqmx.next_segment])
-        self.daqmx.next_segment += 1
-        self.daqmx.clock.stop()
-
-        # test for end of frame
-        if self.daqmx.next_segment == self.segment_count:
-            self.daqmx.next_segment = -1
-
-
-class CompoundDAQmx:
-    def __init__(self, dmgr, daqmx_device, clock_device, channel_count,
-                 sample_rate, sample_rate_in_mu=False):
-        self.core = dmgr.get("core")
-        self.daqmx = dmgr.get(daqmx_device)
-        self.clock = dmgr.get(clock_device)
-        self.channel_count = channel_count
-        if sample_rate_in_mu:
-            self.sample_rate = sample_rate
-        else:
-            self.sample_rate = self.clock.frequency_to_ftw(sample_rate)
-
-        self.frame = None
-        self.next_segment = -1
-        self.armed = False
-
-    def disarm(self):
-        if self.frame is not None:
-            self.frame._invalidate()
-        self.frame = None
-        self.armed = False
-
-    def arm(self):
-        if self.armed:
-            raise ArmError
-        if self.frame is not None:
-            self.frame._arm()
-            self.daqmx.load_sample_values(
-                self.clock.ftw_to_frequency(self.sample_rate),
-                np.array(self.frame._get_samples()))
-        self.armed = True
-
-    def create_frame(self):
-        if self.armed:
-            raise ArmError
-        self.frame = _Frame(self)
-        return self.frame
diff --git a/artiq/frontend/pxi6733_controller.py b/artiq/frontend/pxi6733_controller.py
deleted file mode 100755
index b0270f2a6..000000000
--- a/artiq/frontend/pxi6733_controller.py
+++ /dev/null
@@ -1,48 +0,0 @@
-#!/usr/bin/env python3.5
-# Yann Sionneau <ys@m-labs.hk>, 2015
-
-import argparse
-import sys
-
-from artiq.protocols.pc_rpc import simple_server_loop
-from artiq.devices.pxi6733.driver import DAQmx, DAQmxSim
-from artiq.tools import *
-
-
-def get_argparser():
-    parser = argparse.ArgumentParser(description="NI PXI 6733 controller")
-    simple_network_args(parser, 3256)
-    parser.add_argument("-C", "--channels", default=None,
-                        help="List of channels (e.g. Dev1/ao0, Dev1/ao1:3).")
-    parser.add_argument("-c", "--clock", default="PFI5",
-                        help="Input clock pin name (default: PFI5)")
-    parser.add_argument("--simulation", action='store_true',
-                        help="Put the driver in simulation mode, even if "
-                             "--channels is used.")
-    verbosity_args(parser)
-    return parser
-
-
-def main():
-    args = get_argparser().parse_args()
-    init_logger(args)
-
-    if not args.simulation and args.channels is None:
-        print("You need to specify either --simulation or -C/--channels "
-              "argument. Use --help for more information.")
-        sys.exit(1)
-
-    if args.simulation:
-        daq = DAQmxSim()
-    else:
-        daq = DAQmx(args.channels,
-                    args.clock)
-
-    try:
-        simple_server_loop({"pxi6733": daq},
-                           bind_address_from_args(args), args.port)
-    finally:
-        daq.close()
-
-if __name__ == "__main__":
-    main()
diff --git a/artiq/test/pxi6733.py b/artiq/test/pxi6733.py
deleted file mode 100644
index cbeccf273..000000000
--- a/artiq/test/pxi6733.py
+++ /dev/null
@@ -1,41 +0,0 @@
-import unittest
-import os
-import numpy as np
-
-from artiq.devices.pxi6733.driver import DAQmxSim, DAQmx
-
-
-pxi6733_device = os.getenv("PXI6733_DEVICE")
-pxi6733_analog_output = os.getenv("PXI6733_ANALOG_OUTPUT")
-pxi6733_clock = os.getenv("PXI6733_CLOCK")
-
-
-class GenericPXI6733Test:
-    def test_load_sample_values(self):
-        test_vector = np.array([1.0, 2.0, 3.0, 4.0], dtype=float)
-        self.cont.load_sample_values(test_vector)
-
-    def test_close_1(self):
-        self.cont.close()
-
-    def test_close_2(self):
-        test_vector = np.array([1.0, 2.0, 3.0, 4.0], dtype=float)
-        self.cont.load_sample_values(test_vector)
-        self.cont.close()
-
-
-@unittest.skipUnless(pxi6733_device, "no hardware")
-class TestPXI6733(GenericPXI6733Test, unittest.TestCase):
-    def setUp(self):
-        args = dict()
-        args["device"] = bytes(pxi6733_device, "ascii")
-        args["analog_output"] = bytes(pxi6733_analog_output, "ascii") \
-            if pxi6733_analog_output else b"ao0"
-        args["clock"] = bytes(pxi6733_clock, "ascii") \
-            if pxi6733_clock else b"PFI5"
-        self.cont = DAQmx(**args)
-
-
-class TestPXI6733Sim(GenericPXI6733Test, unittest.TestCase):
-    def setUp(self):
-        self.cont = DAQmxSim()
diff --git a/conda/artiq/meta.yaml b/conda/artiq/meta.yaml
index 1bc4d33e3..28b474860 100644
--- a/conda/artiq/meta.yaml
+++ b/conda/artiq/meta.yaml
@@ -27,7 +27,6 @@ build:
     - novatech409b_controller = artiq.frontend.novatech409b_controller:main
     - pdq2_client = artiq.frontend.pdq2_client:main
     - pdq2_controller = artiq.frontend.pdq2_controller:main
-    - pxi6733_controller = artiq.frontend.pxi6733_controller:main
     - thorlabs_tcube_controller = artiq.frontend.thorlabs_tcube_controller:main
 
 requirements:
@@ -47,7 +46,6 @@ requirements:
     - sphinx-argparse
     - h5py
     - dateutil
-    - pydaqmx
     - quamash
     - pyqtgraph
     - pygit2
diff --git a/doc/manual/default_network_ports.rst b/doc/manual/default_network_ports.rst
index 1b787724e..badbfd609 100644
--- a/doc/manual/default_network_ports.rst
+++ b/doc/manual/default_network_ports.rst
@@ -28,5 +28,3 @@ Default network ports
 +--------------------------+--------------+
 | Thorlabs T-Cube          | 3255         |
 +--------------------------+--------------+
-| NI PXI6733               | 3256         |
-+--------------------------+--------------+
diff --git a/doc/manual/ndsp_reference.rst b/doc/manual/ndsp_reference.rst
index 3c41d7287..aab38f1e1 100644
--- a/doc/manual/ndsp_reference.rst
+++ b/doc/manual/ndsp_reference.rst
@@ -170,49 +170,3 @@ Then, send commands to it via the ``artiq_rpctool`` utility::
     $ artiq_rpctool ::1 3255 call set_tpz_io_settings 150 1 # set maximum output voltage to 150 V
     $ artiq_rpctool ::1 3255 call set_output_volts 150 # set output voltage to 150 V
     $ artiq_rpctool ::1 3255 call close # close the device
-
-NI PXI6733
-----------
-
-Driver
-++++++
-
-.. automodule:: artiq.devices.pxi6733.driver
-    :members:
-
-Controller
-++++++++++
-
-.. argparse::
-   :ref: artiq.frontend.pxi6733_controller.get_argparser
-   :prog: pxi6733_controller
-
-PXI6733 controller usage example
-++++++++++++++++++++++++++++++++
-
-This controller has only been tested on Windows so far.
-
-To use this controller you need first to install the NI-DAQmx driver
-from http://www.ni.com/downloads/ni-drivers/f/.
-
-Then you also need to install PyDAQmx python module::
-
-    $ git clone https://github.com/clade/PyDAQmx
-    $ cd PyDAQmx
-    $ C:\Python34\Tools\Scripts\2to3.py -w .
-    $ python setup.py build
-    $ python setup.py install
-
-Then, you can run the PXI6733 controller::
-
-    $ pxi6733_controller -d Dev1
-
-Then, send a load_sample_values command to it via the ``artiq_rpctool`` utility::
-
-    $ artiq_rpctool ::1 3256 list-targets
-    Target(s):   pxi6733
-    $ artiq_rpctool ::1 3256 call load_sample_values 'np.array([1.0, 2.0, 3.0, 4.0], dtype=float)'
-
-This loads 4 voltage values as a numpy float array: 1.0 V, 2.0 V, 3.0 V, 4.0 V
-
-Then the device is set up to output those samples at each rising edge of the clock.
diff --git a/setup.py b/setup.py
index ee6cf7920..1f5c651bd 100755
--- a/setup.py
+++ b/setup.py
@@ -12,7 +12,7 @@ if sys.version_info[:3] < (3, 5, 1):
 
 requirements = [
     "sphinx", "sphinx-argparse", "pyserial", "numpy", "scipy",
-    "python-dateutil", "prettytable", "h5py", "pydaqmx",
+    "python-dateutil", "prettytable", "h5py",
     "quamash", "pyqtgraph", "pygit2", "aiohttp",
     "llvmlite_artiq", "pythonparser", "python-Levenshtein",
     "lit", "OutputCheck",
@@ -36,7 +36,6 @@ scripts = [
     "novatech409b_controller=artiq.frontend.novatech409b_controller:main",
     "pdq2_client=artiq.frontend.pdq2_client:main",
     "pdq2_controller=artiq.frontend.pdq2_controller:main",
-    "pxi6733_controller=artiq.frontend.pxi6733_controller:main",
     "thorlabs_tcube_controller=artiq.frontend.thorlabs_tcube_controller:main",
 ]