diff --git a/artiq/compiler/targets.py b/artiq/compiler/targets.py
index 853d6c3eb..5c74e4120 100644
--- a/artiq/compiler/targets.py
+++ b/artiq/compiler/targets.py
@@ -239,6 +239,9 @@ class NativeTarget(Target):
     def __init__(self):
         super().__init__()
         self.triple = llvm.get_default_triple()
+        host_data_layout = str(llvm.targets.Target.from_default_triple().create_target_machine().target_data)
+        assert host_data_layout[0] in "eE"
+        self.little_endian = host_data_layout[0] == "e"
 
 class OR1KTarget(Target):
     triple = "or1k-linux"
@@ -246,3 +249,4 @@ class OR1KTarget(Target):
                   "f64:32:32-v64:32:32-v128:32:32-a0:0:32-n32"
     features = ["mul", "div", "ffl1", "cmov", "addc"]
     print_function = "core_log"
+    little_endian = False
diff --git a/artiq/compiler/transforms/llvm_ir_generator.py b/artiq/compiler/transforms/llvm_ir_generator.py
index fa619d48c..fdcbe8ab3 100644
--- a/artiq/compiler/transforms/llvm_ir_generator.py
+++ b/artiq/compiler/transforms/llvm_ir_generator.py
@@ -150,10 +150,6 @@ class LLVMIRGenerator:
             ll.Constant(lli64, 1)
         ])
 
-        data_layout = str(self.lldatalayout)
-        assert data_layout[0] in "eE"
-        self.little_endian = data_layout[0] == "e"
-
     def needs_sret(self, lltyp, may_be_large=True):
         if isinstance(lltyp, ll.VoidType):
             return False
@@ -1160,7 +1156,7 @@ class LLVMIRGenerator:
             lltime_lo = self.llbuilder.trunc(lltime, lli32)
             llnow_hiptr = self.llbuilder.bitcast(self.llbuiltin("now"), lli32.as_pointer())
             llnow_loptr = self.llbuilder.gep(llnow_hiptr, [self.llindex(1)])
-            if self.little_endian:
+            if self.target.little_endian:
                 lltime_hi, lltime_lo = lltime_lo, lltime_hi
             llstore_hi = self.llbuilder.store_atomic(lltime_hi, llnow_hiptr, ordering="seq_cst", align=4)
             llstore_lo = self.llbuilder.store_atomic(lltime_lo, llnow_loptr, ordering="seq_cst", align=4)
@@ -1175,7 +1171,7 @@ class LLVMIRGenerator:
             lladjusted_lo = self.llbuilder.trunc(lladjusted, lli32)
             llnow_hiptr = self.llbuilder.bitcast(llnowptr, lli32.as_pointer())
             llnow_loptr = self.llbuilder.gep(llnow_hiptr, [self.llindex(1)])
-            if self.little_endian:
+            if self.target.little_endian:
                 lladjusted_hi, lladjusted_lo = lladjusted_lo, lladjusted_hi
             llstore_hi = self.llbuilder.store_atomic(lladjusted_hi, llnow_hiptr, ordering="seq_cst", align=4)
             llstore_lo = self.llbuilder.store_atomic(lladjusted_lo, llnow_loptr, ordering="seq_cst", align=4)