diff --git a/pytec/autotune.py b/pytec/autotune.py
index 360d06c..f9e9bc1 100644
--- a/pytec/autotune.py
+++ b/pytec/autotune.py
@@ -17,6 +17,7 @@ class PIDAutotuneState(Enum):
     STATE_RELAY_STEP_DOWN = 'relay step down'
     STATE_SUCCEEDED = 'succeeded'
     STATE_FAILED = 'failed'
+    STATE_READY = "ready"
 
 
 class PIDAutotune:
@@ -56,6 +57,21 @@ class PIDAutotune:
         self._Ku = 0
         self._Pu = 0
 
+    def setParam(self, target, step, noiseband, sampletime, lookback):
+        self._setpoint = target
+        self._outputstep = step
+        self._out_max = step
+        self._out_min = -step
+        self._noiseband = noiseband
+        self._inputs = deque(maxlen=round(lookback / sampletime))
+
+    def setReady(self):
+        self._state = PIDAutotuneState.STATE_READY
+        self._peak_count = 0
+
+    def setOff(self):
+        self._state = PIDAutotuneState.STATE_OFF
+
     def state(self):
         """Get the current state."""
         return self._state
@@ -81,6 +97,13 @@ class PIDAutotune:
         kd = divisors[2] * self._Ku * self._Pu
         return PIDAutotune.PIDParams(kp, ki, kd)
 
+    def get_tec_pid(self):
+        divisors = self._tuning_rules["tyreus-luyben"]
+        kp = self._Ku * divisors[0]
+        ki = divisors[1] * self._Ku / self._Pu
+        kd = divisors[2] * self._Ku * self._Pu
+        return kp, ki, kd
+
     def run(self, input_val, time_input):
         """To autotune a system, this method must be called periodically.
 
diff --git a/pytec/pytec/gui/model/pid_autotuner.py b/pytec/pytec/gui/model/pid_autotuner.py
new file mode 100644
index 0000000..c916a21
--- /dev/null
+++ b/pytec/pytec/gui/model/pid_autotuner.py
@@ -0,0 +1,84 @@
+from PyQt6.QtCore import QObject, pyqtSlot, pyqtSignal
+from qasync import asyncSlot
+from autotune import PIDAutotuneState, PIDAutotune
+
+
+class PIDAutoTuner(QObject):
+    autotune_state_changed = pyqtSignal(int, PIDAutotuneState)
+
+    def __init__(self, parent, thermostat, num_of_channel):
+        super().__init__(parent)
+
+        self._thermostat = thermostat
+        self._thermostat.report_update.connect(self.tick)
+
+        self.autotuners = [PIDAutotune(25) for _ in range(num_of_channel)]
+        self.target_temp = [20.0 for _ in range(num_of_channel)]
+        self.test_current = [1.0 for _ in range(num_of_channel)]
+        self.temp_swing = [1.5 for _ in range(num_of_channel)]
+        self.lookback = [3.0 for _ in range(num_of_channel)]
+        self.sampling_interval = [1 / 16.67 for _ in range(num_of_channel)]
+
+    def set_params(self, params_name, ch, val):
+        getattr(self, params_name)[ch] = val
+
+    def get_state(self, ch):
+        return self.autotuners[ch].state()
+
+    def load_params_and_set_ready(self, ch):
+        self.autotuners[ch].setParam(
+            self.target_temp[ch],
+            self.test_current[ch] / 1000,
+            self.temp_swing[ch],
+            1 / self.sampling_interval[ch],
+            self.lookback[ch],
+        )
+        self.autotuners[ch].setReady()
+        self.autotune_state_changed.emit(ch, self.autotuners[ch].state())
+
+    async def stop_pid_from_running(self, ch):
+        self.autotuners[ch].setOff()
+        self.autotune_state_changed.emit(ch, self.autotuners[ch].state())
+        if self._thermostat.connected():
+            await self._thermostat.set_param("output", ch, "i_set", 0)
+
+    @asyncSlot(list)
+    async def tick(self, report):
+        for channel_report in report:
+            ch = channel_report["channel"]
+
+            self.sampling_interval[ch] = channel_report["interval"]
+
+            # TODO: Skip when PID Autotune or emit error message if NTC is not connected
+            if channel_report["temperature"] is None:
+                continue
+
+            match self.autotuners[ch].state():
+                case (
+                    PIDAutotuneState.STATE_READY
+                    | PIDAutotuneState.STATE_RELAY_STEP_UP
+                    | PIDAutotuneState.STATE_RELAY_STEP_DOWN
+                ):
+                    self.autotuners[ch].run(
+                        channel_report["temperature"], channel_report["time"]
+                    )
+                    await self._thermostat.set_param(
+                        "output", ch, "i_set", self.autotuners[ch].output()
+                    )
+                case PIDAutotuneState.STATE_SUCCEEDED:
+                    kp, ki, kd = self.autotuners[ch].get_tec_pid()
+                    self.autotuners[ch].setOff()
+                    self.autotune_state_changed.emit(ch, self.autotuners[ch].state())
+
+                    await self._thermostat.set_param("pid", ch, "kp", kp)
+                    await self._thermostat.set_param("pid", ch, "ki", ki)
+                    await self._thermostat.set_param("pid", ch, "kd", kd)
+                    await self._thermostat.set_param("output", ch, "pid")
+
+                    await self._thermostat.set_param(
+                        "pid", ch, "target", self.target_temp[ch]
+                    )
+                case PIDAutotuneState.STATE_FAILED:
+                    self.autotuners[ch].setOff()
+                    self.autotune_state_changed.emit(ch, self.autotuners[ch].state())
+                    await self._thermostat.set_param("output", ch, "i_set", 0)
diff --git a/pytec/tec_qt.py b/pytec/tec_qt.py
index b10b5c6..327e019 100755
--- a/pytec/tec_qt.py
+++ b/pytec/tec_qt.py
@@ -8,7 +8,9 @@ from PyQt6 import QtWidgets, QtGui, uic
 from PyQt6.QtCore import pyqtSlot
 import qasync
 from qasync import asyncSlot, asyncClose
+from autotune import PIDAutotuneState
 from pytec.gui.model.thermostat import Thermostat, ThermostatConnectionState
+from pytec.gui.model.pid_autotuner import PIDAutoTuner
 from pytec.gui.view.zero_limits_warning_view import ZeroLimitsWarningView
 from pytec.gui.view.thermostat_settings_menu import ThermostatSettingsMenu
 from pytec.gui.view.connection_details_menu import ConnectionDetailsMenu
@@ -55,6 +57,19 @@ class MainWindow(QtWidgets.QMainWindow):
             self._on_connection_state_changed
         )
 
+        self._autotuners = PIDAutoTuner(self, self._thermostat, 2)
+        self._autotuners.autotune_state_changed.connect(
+            self._on_pid_autotune_state_changed
+        )
+
+        # Handlers for disconnections
+        async def autotune_disconnect():
+            for ch in range(self.NUM_CHANNELS):
+                if self._autotuners.get_state(ch) != PIDAutotuneState.STATE_OFF:
+                    await self._autotuners.stop_pid_from_running(ch)
+
+        self._thermostat.disconnect_cb = autotune_disconnect
+
         @pyqtSlot()
         def handle_connection_error():
             self._info_box.display_info_box(
@@ -117,6 +132,28 @@ class MainWindow(QtWidgets.QMainWindow):
                 self.connect_btn.setText("Connect")
                 self.status_lbl.setText("Disconnected")
 
+    @pyqtSlot(int, PIDAutotuneState)
+    def _on_pid_autotune_state_changed(self, _ch, _state):
+        autotuning_channels = []
+        for ch in range(self.NUM_CHANNELS):
+            if self._autotuners.get_state(ch) in {
+                PIDAutotuneState.STATE_READY,
+                PIDAutotuneState.STATE_RELAY_STEP_UP,
+                PIDAutotuneState.STATE_RELAY_STEP_DOWN,
+            }:
+                autotuning_channels.append(ch)
+
+        if len(autotuning_channels) == 0:
+            self.background_task_lbl.setText("Ready.")
+            self.loading_spinner.hide()
+            self.loading_spinner.stop()
+        else:
+            self.background_task_lbl.setText(
+                f"Autotuning channel {autotuning_channels}..."
+            )
+            self.loading_spinner.start()
+            self.loading_spinner.show()
+
     @asyncSlot()
     async def on_connect_btn_clicked(self):
         match self._thermostat.connection_state: